Sunday, August 9, 2020

What If The Cure For COVID-19 Already Existed For Decades?

DISCLAIMER:  The following article references third-party sources and is intended for general information only, and is NOT intended to provide medical advice or otherwise diagnose, treat, cure, or prevent any disease, including (but not limited to) COVID-19.  Consult a qualified physician before beginning any sort of treatment or prophylactic regimen and/or if you know or suspect that you currently have COVID-19.  Anyone who takes or does anything mentioned (or alluded to) in this or any other TSAP article does so entirely at their own risk and liability.  The TSAP thus makes absolutely no warranties, express or implied, and is not liable for any direct, indirect, special, incidental, consequential, or punitive damages resulting from any act or omission on the part of the reader(s) or others.  Caveat lector.

For a more succinct and updated version of this article, please see Part 2 here.

What if the cure for COVID-19 already existed, not just recently, but for decades?  What if the death toll past, present, and future could be or have been reduced to a mere tiny fraction of what it is and is predicted to be without it?  What if it was such a game-changer that it would make vaccines and expensive new drugs obsolete, to say nothing of returning very quickly, seamlessly, and fearlessly to the "old normal" that we all miss so much now (that is, if we would have ever even departed from it at all)?  And what if it consisted entirely of relatively safe and cheap generics and nutritional supplements all along?

Sounds too good to be true, right?  Well, apparently it is true after all, despite all the best efforts of hyper-partisan lockdown enthusiasts, Big Pharma, and their government enablers to suppress and sabotage it.  More and more doctors and scientists all over the world are learning about it every day, in fact.

First, let's define the term "cure" for the purposes of this article.  We do not mean a "silver bullet" type of treatment in the same way that antibiotics singlehandedly cure bacterial infections, since this type of virus, like the common cold and flu, is really defeated by our bodies' own immune systems.  Usually that does the job just fine, but clearly not always.  Sometimes it needs a little help from outside.  Thus, we define a "cure" as any treatment protocol that reduces the death rate and/or hospitalization rate dramatically (by at least 50%) compared to no such treatment, and can thus be considered a game-changer.  Anything that can save that many lives and/or free up that many hospital resources would indeed be a game-changer by definition.

There is in fact already such a certain alternative treatment protocol that has gotten such a bad rap in the mainstream due to grossly improper use (and its infamous guilt by association with certain politicians who promoted it) that some countries and states have even banned it (or at least a key component of it) despite its rather promising effectiveness in saving lives when used early, properly, and under the advice of a qualified physician.  For example, Switzerland briefly banned it and subsequently lifted the ban, effectively creating a natural experiment, and the results speak for themselves in terms of death rates (which rose fourfold during the ban and then dropped back to what they were before the ban when it was lifted).  And the Brazilian state of Para saw death rates plummet after introducing it, while India's rather low per capita death rate (despite their epidemic being out of control for months) can also perhaps be explained by such treatment.

In fact, it seems to be one of the strongest factors in predicting a country's (or region's) per capita death rate, especially after adjusting for the average age of the population.  Meanwhile, the presence or relative stringency of lockdowns generally shows no clear correlation and in fact, within Europe and within the USA, a rather perverse correlation with death rates.

So what is this treatment protocol?  There are several variants, but the one that seems to be the best of all is the one developed and further refined by a group of Swiss doctors, and is as follows in their words:
Treatment protocol
  1. Zinc (50mg to 100mg per day)º
  2. Hydr*xychl*roqu*ne (400mg per day)*
  3. Quercetin (500mg to 1000mg per day)º
  4. Bromhexine (50mg to 100mg per day)º
  5. Azithromycin (up to 500mg per day)*
  6. Heparin (usual dosage)*
*) Prescription only (in most countries)
º) Also prophylactically (for high-risk persons) 
Note: Quercetin may be used in addition to or as a replacement of hydr*xychl*roqu*ne (HCQ). Contraindications for HCQ (e.g. favism or heart disease) and azithromycin must be observed. Treatment duration is five to seven days. Prophylactic treatment requires lower doses.
Their original protocol prior to August 5, 2020 did not include Bromhexine, but that was added due to recently mounting evidence that it is at least as much of a game-changer as HCQ if not more so.  While it is typically used as a mucolytic expectorant for coughs and chest congestion, apparently it can also incidentally prevent the virus from getting into our cells in the first place, thus rendering the virus impotent in the face of treatment.  While Bromhexine is available over the counter (OTC) in most countries worldwide including the UK, EU, Australia, Mexico, and much of Asia, it is unfortunately still not available yet in the USA as the FDA has yet to approve it, so Americans would likely have to stick to the original five-component version for the time being unless they are currently abroad.  That is probably why most Americans have probably never even heard of it.

So how does the whole thing work?  This synergistic cocktail does the following, in their own words, with linked citations:
Mechanisms of action 
Zinc inhibits RNA polymerase activity of coronaviruses and thus blocks virus replication. Hydr*xychl*roqu*ne and quercetin support the cellular absorption of zinc and have additional anti-viral propertiesBromhexine inhibits the expression of the cellular TMPRSS2 protease and thus the entry of the virus into the cell. Azithromycin prevents bacterial superinfections. Heparin prevents infection-related thromboses and embolisms in patients at risk. (See scientific references below). 
See alsoIllustration of the mechanisms of action of HCQ, quercetin and bromhexine
The Swiss doctors do note that early treatment is best, ideally before hospitalization, as is prophylactic use for high-risk and high-exposure persons.  The sooner, the better.  If taken too late, such as when already in critical condition, its usefulness is quite limited.  But even if already hospitalized, better late than never.

So exactly how successful are we talking here?  Again, in their own words:
Treatment successes 
Zinc/HCQ/AZ: US physicians reported an 84% decrease in hospitalization rates, a 50% decrease in mortality rates among already hospitalized patients (if treated early), and an improvement in the condition of patients within 8 to 12 hours. Italian doctors reported a decrease in deaths of 66%. 
Bromhexine: Iranian doctors reported in a study with 78 patients a decrease in intensive care treatments of 82%, a decrease in intubations of 89%, and a decrease in deaths of 100%. Chinese doctors reported a 50% reduction in intubations.
Pretty impressive, right?  Let those numbers sink in for a moment.  Talk about a game-changer!

And if one still needs to be hospitalized, they go on to recommend that ventilators be avoided as much as possible as they tend to be counterproductive, and opt instead for the far less-invasive high-flow nasal cannula (HFNC) to deliver live oxygen therapy.

(Courtesy of Swiss Policy Research.  Worth reading in full from the original source.)

A word of caution about HCQ:  While it seems to work very well when used early, properly, and under the advice of a qualified physician, that does NOT mean that anyone should just take it willy-nilly.  Ditto for azithromycin or any other antibiotic.  These powerful drugs can have serious side effects when taken improperly, excessively, or when medically contraindicated, which is why they are still prescription-only in most (but not all) countries even after decades of being on the market.  Don't hoard them either, since plenty of non-COVID patients also depend on these medications as well.  Don't take (H)CQ with any drug that prolongs the QT interval either. And unless you really, really want to win a Darwin Award, do NOT ingest any fish tank cleaner just because it happens to be related and has a similar name!  When in doubt, stick with Quercetin and zinc, with of course plenty of vitamin C and D as well to further boost the immune system and synergize with the former.

(Quercetin, a naturally occurring plant bioflavonoid found in various foods, is readily available as a nutritional supplement in numerous stores nationwide and worldwide.  The TSAP likes to affectionately call it "Vitamin Q". And no one would dare to ban that, of course, since doing so would just give the game away at this point.  They'd rather simply ignore it and pretend it doesn't exist.)

And of course, for any critical cases, we know now (through clinical trial and error) that there are always corticosteroids to fall back on as well, particularly dexamethasone, and possibly inhaled ones like budesonide as well.  Their effectiveness in saving lives is apparently good but limited.  Given that they inherently suppress the immune system, they should NOT be given early, only for cases that are bad enough that respiratory support is needed.  That is, steroids are used to quell the dreaded "cytokine storm" of severe inflammation that occurs when the body basically nukes itself in a desperate (and counterproductive) attempt to rid it of the virus.  The fact that it took months to figure that out really speaks volumes.  And it is practically the only thing that both pro-HCQ and anti-HCQ studies seem to agree upon.

(The jury is still out on whether early budesonide use specifically has any additional benefits.)

Also, please note that the TSAP is NOT a Trump-supporting party, in fact we despise him and want him to lose the 2020 election.  But as we know, sometimes a stopped clock can be right twice a day in regards to HCQ, albeit with the truth being a bit more nuanced.  And he could partially and belatedly atone for some of his misdeeds with the simple stroke of his executive pen, namely by passing an emergency use (if not permanent) authorization for the importation, manufacture, and use of Bromhexine.  If countries as strict as the UK and Australia can approve it long ago for OTC use, surely we can do the same over here.  And also, make low-dose HCQ OTC (or at least behind the counter) as well, like several countries already do, perhaps subject to rationing.

(And, of course, Trump can also use the Defense Production Act to force the production and distribution of PPE to hospitals, albeit belatedly, so nurses don't have to keep reusing PPE.  And then he can go do us all a YUUUGE favor and RESIGN.)

In fact, we will go out on a limb and make the following extremely audacious claim:  Had the United States government (as well as other countries) decided instead to avoid lockdowns and shutdowns entirely, let the virus run its course, and simply made all of the aforementioned drugs in this article readily available for free or cheap from the start to all those who needed them, especially for high-risk and high-exposure groups, while also recommending and providing the general population with vitamins C and D, Quercetin, and zinc, we would very likely have saved a LOT more lives at a tiny fraction of the cost.  And of course, no collateral damage either.  But that would have made far too much sense, of course.

Thus, the cure has apparently been right under our noses all along.  It is long past time to stop playing politics and put it to good use, ending this nightmare once and for all.  So what are we waiting for?

UPDATE:  As of August 25, 2020, and again in September, the Swiss doctors have since updated their treatment protocol with some new nuances added, and clearer distinctions between treatment and prophylaxis.  They also add Vitamins C and D as well to both treatment and prophylaxis.  As an aside, they also now add that ivermectin and favipiravir may also be rather promising treatments as well (though note how they do NOT mention Gilead's overpriced blockbuster drug remdesivir, which quite honestly is at best just another Tamiflu but with more side effects). The basic idea here is the same though.  To wit, in their own words below:

Treatment protocol

Prophylaxis

  1. Zinc (50mg to 100mg per day)
  2. Quercetin (500mg to 1000mg per day)
  3. Bromhexine (25mg to 50mg per day)
  4. Vitamins C (1000mg) and D (2000 u/d)

Early treatment

  1. Zinc (75mg to 150mg per day)
  2. Quercetin (500mg to 1500mg per day)
  3. Bromhexine (50mg to 75mg per day)
  4. Vitamins C (1000mg) and D (4000 u/d)

Ancillary (prescription only)

  1. Hydr*xychlor*qu*ne (400mg per day)
  2. High-dose vitamin D (1x 100,000 IU)
  3. Azithromycin (up to 500mg per day)
  4. Heparin (usual dosage)
Note: Contraindications for HCQ (e.g. favism or heart disease) must be observed. 
Addendum: Other prescription drugs with first reported successes in the early medical treatment of Covid-19 are ivermectin (read more) and favipiravir (read more).
And there you have it.  Note that while HCQ and azithromycin have been demoted to merely "ancillary", that is probably because of the addition of Bromhexine, which again is unfortunately still not available in the USA at all except in small clinical trials.  (WTF are they waiting for?)  So to any Americans reading this, if your doctor says that you need HCQ and/or azithromycin, then you probably really do, and should thus take it without delay.

There is also another treatment and prophylaxis protocol by Dr. Shiva Ayyadurai involving Vitamin A and iodine/iodide as well as Vitamins C and D to build up one's immune system worth considering as well.  Please do be careful with Vitamin A though, since unlike with C and D, it is fairly easy to overdose on.  Ditto for Lugol's iodine solution as well.

NEW UPDATE: As of September 9, 2020, there is a new hypothesis, the bradykinin hypothesis, which posits that the main way that COVID-19 kills is via a bradykinin storm rather than a purely cytokine storm, though the two storms are likely intertwined.  If that's the case, then there are various additional existing drugs that target the renin-angiotensin system (RAS), and it also further strengthens the case for Vitamin D as a treatment and prophylaxis, for which evidence continues to mount as we speak.

In fact, the Swiss doctors just recently added a very high-dose bolus of Vitamin D to the ancillary category of their protocol, based on the very promising results of a recent randomized clinical trial in Spain.

Nutrition in general seems to play a key role in who survives COVID and who doesn't.  And not just Vitamin C and D--there several other important nutrients worth considering as well.  For example, glutathione, and the supplement N-acetylcysteine (NAC), which is a key precursor to glutathione, also seems to have rather promising effects as well.  NAC is also a good liver detox and hangover cure as well, which is probably what it is most famous for.  Selenium, and also EGCG from green tea, look rather promising as well.  And, of course, as noted earlier in this article, whatever you do, don't forget the zinc!

Stay healthy everyone,

The True Spirit of America Party

5 comments:

  1. FINALLY AJAX YOU'RE ON MY PAGE WITH THESE DISEASES, WHAT I HAVE BEEN SAYING ALL ALONG. AND THANK YOU FOR THE RESEARCH. I AGREE WITH THE STATEMENTS.

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    Replies
    1. I just added some updates to this article after the Swiss doctors recently updated their website today.

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    2. And yet another update today. Enjoy :)

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